Figure 7. GC of ifosfamide (retention time: 14 min) at different dehalogenation temperatures. At 300°C, N-Lost (retention time at about 7 min, see arrow) is one of the degradation products. Proton source: toluene. Reductant: iron. Top: solvent toluene at 500°C

From

Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide

C. Laauser, G. Habekost, A. Habekost

Applied Ecology and Environmental Sciences. 2018, 6(1), 15-22 doi:10.12691/aees-6-1-3